Spatially distinct cellular and molecular landscapes define prognosis in triple-negative breast cancer.

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PubMedPublished 2026Medicine & Clinical ResearchCancer Research
Journal
Cell reports
Record source
PubMed Research Library

Abstract / Description

Triple-negative breast cancer (TNBC) is a prevalent breast cancer subtype with the lowest 5-year survival. Several factors influence outcomes, but their inherent molecular and cellular heterogeneity are increasingly acknowledged as crucial determinants. Here, we report on the spatio-molecular heterogeneity underlying TNBC tumors in a retrospective, treatment-naive cohort with differential prognoses (17 good prognoses [GPx] >15-year survival and 15 poor prognoses [PPx]
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