Abstract / Description
Background/aimImmune checkpoint inhibitors (ICIs) have been shown to be effective in various cancer subtypes and their use in clinical practice has become widespread in recent years. However, discussions on their effectiveness in geriatric patients and in cases of malnutrition are still ongoing. The aim of the study was to evaluate the association of geriatric nutritional index (GNRI) detected malnutrition risk with progression-free survival (PFS) and immune related adverse events (irAEs) in geriatric solid tumor patients treated with ICIs.Patients and methodsThe study was conducted retrospectively and included patients with metastatic solid tumors who received second- or third-line immunotherapy between 2018 and 2024 at the Dr. Abdurrahman Yurtaslan, Ankara Oncology Education and Research Hospital and Etlik City Hospital. The GNRI score of the patients at the start of immunotherapy was calculated, and the relationship between the GNRI score and PFS and irAEs was evaluated.ResultsNo significant association was found between sex (p=0.28), comorbidity (p=0.34), polypharmacy (p=0.09), antibiotic (p=0.24) use and PFS. A significant association was found between ECOG PS (p