Systemic inflammation and the risk of adverse clinical outcomes in heart failure with preserved ejection fraction.

IntroductionSystemic inflammation is implicated in the pathogenesis of cardiovascular disease, including heart failure (HF). We examined the association between systemic inflammation, indicated by elevated high-sensitivity C-reactive protein (hsCRP), and adverse clinical outcomes in individuals with HF with preserved ejection fraction (HFpEF).MethodsThis retrospective cohort study identified individuals with HFpEF from the Komodo Healthcare Map™ database (01/01/2016 to 12/31/2023) using a validated algorithm. Systemic inflammation status was established by hsCRP testing: with systemic inflammation if ≥1 hsCRP value of 2-10 mg/L and without systemic inflammation if all hsCRP values