Systematic Review and Meta-analysis of Anti-interferon Auto-antibodies in Infectious Diseases.

PurposeTo perform a systematic review and meta-analysis of prevalence and function of anti-interferon auto-antibodies in acute infectious diseases.MethodsWe performed a search on the following electronic bibliographic databases: Medline, Embase, Web of Science and Cochrane. Eligible studies generated a systematic review and random effects model meta-analysis of pooled seroprevalence and neutralisation status of anti-interferon auto-antibodies in acute infectious diseases.ResultsThirty-seven studies including 12,629 individuals with SARS-CoV-2 infection were analysed. There are insufficient data for meta-analyses of auto-antibodies in non-SARS-CoV-2 infectious diseases, with crude seroprevalence of auto-antibodies varying widely (0.0-77.0%). The pooled seroprevalence of anti-IFNɑ and/or anti-IFN⍵ auto-antibodies in individuals with SARS-CoV-2 infection was 14% (95%CI 9-18%, I2 = 92%, [Formula: see text]2 = 0.0151, p