Abstract / Description
PurposePneumonia is still a leading cause of morbidity and death globally, with a significant percentage of cases having an unknown aetiology, and management becoming more difficult due to growing antimicrobial resistance (AMR). This study assessed clinical outcomes, antimicrobial susceptibility patterns, and pathogen detection using both conventional and molecular techniques in hospitalized pneumonia patients in Jordan.Patients and methods111 adults (≥18 years) who were admitted to a tertiary private hospital in Amman between May 2021 and January 2022 with either hospital-acquired (HAP) or community-acquired pneumonia (CAP) were included in this prospective study. Multiplex real-time PCR and conventional culture were performed on lower respiratory tract samples (FTD Respiratory Pathogens 33). Data on outcomes, microbiology, antimicrobial susceptibility, clinical, and demographics were gathered. McNemar's test was used to compare diagnostic performance, and logistic regression and chi-square analyses were used to evaluate the relationships between outcomes and adherence to guidelines.ResultsThe average age was 64.0±20.6 years, and 58.6% of the population was male. 78.4% of cases were CAP. PCR detected pathogens in 74.8% of patients, whereas culture detected them in 57.7% (p