Bacterial profile and antibiotic susceptibility of bloodstream infections among infants, children, and adolescents undergoing treatment for acute leukemia.

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Europe PMCPublished 2026Public Health & EpidemiologyPopulation Health & Disease Prevention
Journal
PloS one
Record source
Europe PMC Research Library

Abstract / Description

IntroductionPediatric patients with acute leukemia are at risk of bacteremia due to disease and treatment-related toxicities. Limited data exists on pathogen distribution across different pediatric age groups. This study aims to investigate the distribution of bacterial pathogens and their susceptibility patterns across infants, children, and adolescents undergoing treatment for acute leukemia.MethodsRetrospective cohort study that included pediatric patients with Acute Lymphoblastic Leukemia (ALL) or Acute Myeloid Leukemia (AML) who had positive blood cultures between 01/01/2015-31/12/2024. Bacteremia was defined as the presence of bacterial microorganisms in the bloodstream, confirmed by one or more positive blood cultures with associated symptoms. Patients were categorized into three age groups: infants (≤1 year), children (>1 to
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