Effect of mesenchymal stem cells on reducing melanin levels in response to UV radiation in male C57BL/6 mice

Melanin is a pigment produced by melanocytes through polymerization and oxidation during melanogenesis. It is present in the skin, hair, and eyes as a natural bodily mechanism, although its levels can increase following damage. Ultraviolet (UV) radiation activates melanogenesis, leading to excess melanin production and elevated reactive oxygen species (ROS) levels, which can result in hyperpigmentation. Thus, this study aimed to explore the potential of mesenchymal stem cells (MSC) as an alternative method to prevent skin hypermelanosis caused by UV radiation in male C57BL/6 mice. The current study examined the effect of MSC therapy on melanin levels in mice exposed to UV radiation using histopathological analysis. Animals were divided into three groups such as normal, UV, and UV+MSC. The results showed that administering MSC reduced melanin levels in UV-exposed mice; however, this reduction was not statistically significant compared to the UV group at a dose of 0.1 cc. In addition, the decrease in melanin levels induced by MSC treatment in UV-exposed mice was confirmed through histopathological analysis. In conclusion, the study suggests the potential of MSC as an alternative strategy for preventing skin hypomelanosis in UV-exposed mice. [ J Adv Biotechnol Exp Ther 2026; 9(1.000): 67-75]